Medication #1: Contrave (Bupropion/Naltrexone)

May 29, 2019 by Kerri Maxcy PA-C

To continue our weight management series, we will now be discussing some of the prescription medications that are available. We are going to start with Contrave.

Contrave is an oral medication that was approved in 2014 for long term weight loss in individuals with a body mass index (BMI) >30 or those with a BMI >27 and another medical condition, such as diabetes, high blood pressure, or high cholesterol. 

It is a combination of two different medications, bupropion and naltrexone.  This medication works in two different areas of your brain to help reduce hunger and control cravings.  Studies have shown a reduction in body weight and improvements in high-density lipoprotein (HDL) or good cholesterol and triglycerides.  Trials have also shown improvements in fasting insulin, insulin resistance, and waist circumference.  When added to a program promoting healthy eating and exercise, the results were even better with 2-4 times the weight loss compared to those that just took the medication.

This medication is not for use in those that have uncontrolled blood pressure, seizure disorder or history of seizures, are on certain medications, or have a history of suicidal behavior. 

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